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Pantoprazole free base of Formula VIII can be converted to pantoprazole sodium of Formula IV by any of the processes described in the literature such as those described in PCT Publication No.

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Control of heartburn strongly predicts improvement in health-related quality of life during the acute treatment of GERD ().

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Scheme 3 As may be seen, different synthesis strategies have been proposed for the preparation of pantoprazole, some of them recently, which is an indication that the preparation of the product is still not considered to be sufficiently well developed, whereby there is still a need for developing alternative processes that allow pantoprazole to be prepared by means of simpler techniques and more accessible intermediate compounds and with good chemical yields.

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After administration of a single intravenous dose of 14C-labeled pantoprazole to healthy, normal metabolizer subjects, approximately 71% of the dose was excreted in the urine with 18% excreted in the feces through biliary excretion.

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Zollinger-Ellison Syndrome is a rare and potentially deadly disease that typically affects those between the ages of 30 and 50.

A generic drug simply means that the drug is not made by the original manufacturer, the chemical is exactly the same.

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The pharmacokinetics of pantoprazole are linear after both oral and IV administration, with area under the curve (AUC) and C max increasing in proportion to IV doses up to 240 mg.

It looks to me like the other side effects for Pantoprazole may be worse than those of Omeprozole.

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

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Thus GERD results in a significant cost burden.

There was no statistically significant difference between pantoprazole sodium and placebo in the rate of discontinuation.

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Thus, not only were esomeprazole and omeprazole treatments comparable but also esomeprazole 40 mg and esomeprazole 20 mg od did not yield significantly different results after 4 weeks in patients with NERD ().

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Pantoprazole sodium was not found to be effective in a multicenter, randomized, double-blind, placebo-controlled, treatment-withdrawal study of 129 pediatric patients 1 through 11 months of age.

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PPI as it worked well in the past but I have been reading that Omepozole also can cause liver toxicity and both my doc and I are nervous about my starting it up again since we can't really be sure if it was the Simvastatin, the Omeprozole, or the combination that caused the hepatitis.

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Musculoskeletal aches side effects have been reported in approximately 1% of patients.

Pantoprazole sodium delayed-release tablets are a prescription medicine called a proton pump inhibitor (PPI).

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It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pantoprazole.

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